反应详情

320 mg (1.20 mmol) of 4-(3-chlorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid was dissolved in 2 ml of DMF. 280 mg (1.20 mmol) of methyl (3-phenyl-2-propene-1-ylamino)acetate and 276 mg (1.44 mmol) of WSC hydrochloride were added to the obtained solution, and they were stirred at room temperature overnight. After the extraction with ethyl acetate, the extract was dried over magnesium sulfate. Ethyl acetate was evaporated under reduced pressure. The residue was purified by the silica gel chromatography (methylene chloride/methanol=200/1 to 50/1) to obtain the title compound.

1. extractionAfter the extraction with ethyl acetate
2. dry with materialthe extract was dried over magnesium sulfate
3. customEthyl acetate was evaporated under reduced pressure
4. customThe residue was purified by the silica gel chromatography (methylene chloride/methanol=200/1 to 50/1)