反应详情

温度

50 °C

To a mixture of N-tert-Butyl-2-(6-fluoro-1-(2,2,2-trifluoroethyl)-1H-indazol-3-yl)-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide (60 mg, 0.12 mmol) in 3 mL of methanol was added concentrated HCl (10 mL). The reaction mixture was heated to 50° C. and stirred overnight. The solvent was evaporated and the residue was triturated with tert-butyl methyl ether, filtered and dried to give N-tert-butyl-2-(6-fluoro-1-(2,2,2-trifluoroethyl)-1H-indazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide as a yellow solid (30 mg, 58%). LCMS: (M+H)+=435; 1H NMR (300 MHz, DMSO): δ 12.86 (s, 1H), 9.04 (s, 1H), 8.52-8.47 (m, 1H), 8.41 (d, 1H, J=3.0 Hz), 7.89-7.83 (m, 2H), 7.26-7.23 (m, 1H), 5.62-5.53 (m, 2H), 1.51 (s, 9H).

1. customThe solvent was evaporated
2. customthe residue was triturated with tert-butyl methyl ether
3. filtrationfiltered
4. customdried