反应详情

To the solution of N-(1-(tert-butyldimethylsilyloxy)-2-methylpropan-2-yl)-2-(1-(3-(dimethylamino)propyl)-6-methyl-1H-indazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide (1 g, 1.78 mmol) in 10 mL of methanol was added 1 mL of concentrated HCl, stirred for 3 hours, the precipitate was filtered and the filter cake was washed with 2-methoxy-2-methylpropane to give 25 mg of 2-(1-(3-(dimethylamino)propyl)-6-methyl-1H-indazol-3-yl)-N-(1-hydroxy-2-methylpropan-2-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide hydrochloride. LCMS: (M+H)+=450; 1H NMR (300 MHz, DMSO): δ 12.84 (s, 1H), 9.55 (s, 1H), 9.14 (s, 1H), 8.49 (d, 1H, J=8.1 Hz), 8.40 (s, 1H), 7.96 (s, 1H), 7.62 (s, 1H), 7.17 (d, 1H, J=8.4 Hz), 4.61-4.58 (m, 2H), 3.67 (s, 2H), 3.21 (s, 2H), 2.82 (s, 6H), 2.55 (s, 3H), 2.33 (brs, 2H), 1.49 (s, 6H).

1. filtrationthe precipitate was filtered
2. washthe filter cake was washed with 2-methoxy-2-methylpropane