反应详情

1.5 g of 4-(2,3-dihydro-2,2-dimethyl-7-benzofuranyloxy)aniline was dissolved in 20 ml of N,N-dimethylformamide, and 0.8 g of N-methoxy-N-methylcarbamoyl chloride was gradually added to this solution at room temperature. After 1.5 hours, N,N-dimethylformamide was distilled off under reduced pressure. The residue was dissolved in ethyl acetate, washed with water and dried over magnesium sulfate. After distilling off the solvent, the residual oily substance was purified by silica gel column chromatography by using a solvent mixture of ethyl acetate/n-hexane=1/4 as the developer, to obtain 1.4 g of compound No. 2 as identified in Table 1.

1. distillationN,N-dimethylformamide was distilled off under reduced pressure
2. dissolutionThe residue was dissolved in ethyl acetate
3. washwashed with water
4. dry with materialdried over magnesium sulfate
5. distillationAfter distilling off the solvent
6. customthe residual oily substance was purified by silica gel column chromatography
7. additiona solvent mixture of ethyl acetate/n-hexane=1/4 as the developer