反应详情

A solution of 8.0 g of 5-acetonyl-3-chloromethyl-1,2,4-oxadiazole, 6.92 g of 3-nitrobenzaldehyde and 5.27 g of methyl 3-aminocrotonate in 20 ml of isopropyl alcohol was heated under reflux for 6 hours. After ice-cooling, the precipitated solid was collected by filtration, washed with cold isopropyl alcohol and dried to give 11.8 g of methyl 1,4-dihydro-2,6-dimethyl-3-(3-chloromethyl-1,2,4-oxadiazol-5-yl)-4-(3-nitrophenyl)pyridine-5-carboxylate as yellow crystals, m.p. 200.5°-201.5° C.

1. temperatureunder reflux for 6 hours
2. temperatureAfter ice-cooling
3. filtrationthe precipitated solid was collected by filtration
4. washwashed with cold isopropyl alcohol
5. customdried