反应详情

The title product of Example 2 (840 mg, 1.96 mmole) was dissolved in 110 ml ethanol, and then hydrogenated at room temperature using 2 psi of hydrogen and 5% palladium on carbon as catalyst. Insolubles were removed by filtration and the filtrate was concentrated in vacuo, and the incompletely reduced residue (as determined by nmr in (CD3)2SO) was again hydrogenated. Purification by high performance chromatography on silica gel (using 30% by volume acetone-hexane) afforded 145 mg of the title compound as an oil. Spectral data indicate complete reduction of the pyranone moiety to the hydroxy-substituted cyclic ether.

1. customhydrogenated at room temperature
2. customInsolubles were removed by filtration
3. concentrationthe filtrate was concentrated in vacuo
4. customPurification by high performance chromatography on silica gel (using 30% by volume acetone-hexane)