反应详情

To a solution of 1-(4-methylphenyl)pyrrole-2-carbonitrile (1.274 g) in tetrahydrofuran (25 ml) was added N-bromosuccinimide (1.776 g) in several portions at ambient temperature. After being stirred for 3 hours at the same temperature, the mixture was concentrated in vacuo. The residue was treated with diethyl ether. The precipitates were removed by filtration and washed with a small amounts of diethyl ether. The filtrates were concentrated in vacuo to give an oily residue, which was purified by silica gel column chromatography (elution by 40% dichloromethane in n-hexane) to yield 4-bromo-1-(4-methylphenyl)pyrrole-2-carbonitrile (1.78 g) as a solid.

1. concentrationthe mixture was concentrated in vacuo
2. additionThe residue was treated with diethyl ether
3. customThe precipitates were removed by filtration
4. washwashed with a small amounts of diethyl ether
5. concentrationThe filtrates were concentrated in vacuo
6. customto give an oily residue, which
7. customwas purified by silica gel column chromatography (elution by 40% dichloromethane in n-hexane)