HCID 19762511, compound → HCID 178483805, compound

HRID 248944Notes

Reaction equation

HRID 248944 reaction equation
[CH3:1][N:2]([CH2:7][CH2:8][CH:9]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][N:11]=1)[CH2:3][CH2:4][CH2:5][NH2:6].[C:22]([NH:24][C:25](=[N:33][CH2:34][CH2:35][S:36][CH2:37][C:38]1[N:39]=[C:40]([NH:43][C:44]([NH2:46])=[NH:45])[S:41][CH:42]=1)OC1C=CC=CC=1)#[N:23]>>[C:22]([NH:24][C:25]([NH:33][CH2:34][CH2:35][S:36][CH2:37][C:38]1[N:39]=[C:40]([NH:43][C:44]([NH2:46])=[NH:45])[S:41][CH:42]=1)=[N:6][CH2:5][CH2:4][CH2:3][N:2]([CH2:7][CH2:8][CH:9]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][N:11]=1)[CH3:1])#[N:23]

Participants

3

Reactant 2

HCID 19762511HCID 19762511, compoundHCID 178512334HCID 178512334, compound

Product 1

HCID 178483805HCID 178483805, compound

Procedure

Preparation is effected analogously to Example 1, using 0.85 g (3 mmol) of N-methyl-N-[3-phenyl-3-(2-pyridyl)propyl]-1,3-propanediamine and 1.12 g (3 mmol) of N-cyano-N'-[2-[[(2-guanidino-4-thiazolyl)methyl]thio]ethyl]-O-phenyl-isourea as starting materials. Working up by chromatography analogously to Example 1 yields the purified title compound in the form of a dry foam; MS (+FAB method): m/z (rel. int.[%])=565 ([M+H]+, 2), 196 (100); IR (KBr): 2162 cm-1 (C≡N). For analytical purposes a sample is converted into the maleic acid salt and recrystallised from ether/isopropanol; m.p.: 110°-112° C. with decomposition.

Workup

  1. customPreparation
  2. customWorking up by chromatography analogously to Example 1 yields the
  3. custompurified title compound in the form of a dry foam
  4. customrecrystallised from ether/isopropanol

Sources & evidence

ORD record
ord-75d7e7a94e504468a408e0495b58ff21
Source dataset
uspto-grants-1993_05
Patent number
US05212187

Reaction notes

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