反应详情

Preparation is effected analogously to Example 63, using 0.74 g (2.6 mmol) of N-methyl-N-[3-phenyl-3-(2-pyridyl)propyl]-1,3-propanediamine, an equimolar amount of 1,1'-carbonyldiimidazole and 0.65 g (2.6 mmol) of 3-[3-(piperidinomethyl)phenoxy]propaneamine as starting materials. Working up by chromatography (eluant: ethyl acetate/methanol 9+1) analogously to Example 63 yields the purified title compound in the form of an oil; MS (+FAB method): m/z (rel. int.[%])=558 ([M+H]+, 11), 196 (100); IR (KBr): 1639 cm-1 (C=O). For analytical purposes a sample is converted into the maleic acid salt and recrystallised from ether/ethanol; m.p.: from 70° C. with decomposition.

1. customPreparation
2. custompurified title compound in the form of an oil
3. customrecrystallised from ether/ethanol
4. customfrom 70° C.