反应详情

Preparation is effected analogously to Example 63, using 0.33 g (1.2 mmol) of N-methyl-N-[3-phenyl-3-(2-pyridyl)propyl]-1,2-ethanediamine, an equimolar amount of 1,1'-carbonyldiimidazole and 0.4 g (1.6 mmol) of 3-[3-(piperidinomethyl)phenoxy]propaneamine in 10 ml of absolute tetrahydrofuran as starting materials. Working up by chromatography (eluant: ethyl acetate) analogously to Example 63 yields the purified title compound in the form of an oil; MS (EI-80 eV): m/z (rel. int.[%])=543 ([M]+, 1), 84 (100). For analytical purposes a sample is converted into the hydrochloride and recrystallised from ether/ethanol; m.p.: from 130° C. with decomposition.

1. customPreparation
2. custompurified title compound in the form of an oil
3. customrecrystallised from ether/ethanol
4. customfrom 130° C.