反应详情

Preparation is effected analogously to Example 63, using 0.89 g (3 mmol) of N-methyl-N-[3-phenyl-3-(2-pyridyl)propyl]-1,4-butanediamine, an equimolar amount of 1,1'-carbonyldiimidazole and 0.75 g (3.2 mmol) of 2-[[(2-guanidino-4-thiazolyl)methyl]thio]ethaneamine as starting materials. Working up by chromatography (eluant: chloroform/methanol 9+1) analogously to Example 63 yields the purified title compound in the form of a dry foam; MS (+FAB method): m/z (rel. int.[%])=555 ([M+H]+ 1), 196 (100); IR (KBr): 1610 cm-1 (C=O). For analytical purposes a sample is converted into the maleic acid salt and recrystallised from ether/ethanol; m.p.: from 80° C. with decomposition.

1. customPreparation
2. custompurified title compound in the form of a dry foam
3. customrecrystallised from ether/ethanol
4. customfrom 80° C.