反应详情

Preparation is effected analogously to Example 63, using 0.8 g (2.4 mmol) of N-[3-(4-chlorophenyl)-3-(2-pyridyl)propyl]-N-methyl-1,4-butanediamine, an equimolar amount of 1,1'-carbonyldiimidazole and 0.5 g (2.9 mmol) of 2-[[(5-methylimidazol-4-yl)methyl]thio]ethaneamine [R. W. Brimblecombe et al., J. Int. Med. Res. 3, 86 (1975)] as starting materials. Working up by chromatography (eluant: ethyl acetate/methanol 9+1) analogously to Example 63 yields the purified title compound in the form of a crystalline solid that is recrystallised from ether; m.p.: 97°-98° C.; MS (+FAB method): m/z (rel. int.[%])=529 ([M+H]+, 10), 230 (100); IR (KBr): 1643 cm-1 (C=O).

1. customPreparation
2. custompurified title compound in the form of a crystalline solid
3. customthat is recrystallised from ether