反应详情

Preparation is effected analogously to Example 63, using 0.63 g (2.0 mmol) of N-[2-[N-(4-fluorobenzyl)-N-(2-pyridyl)amino]ethyl]-N-methyl-1,3-propanediamine and the equimolar amounts of 1,1'-carbonyldiimidazole and 3-[3-(piperidinomethyl)phenoxy]propylamine as starting materials. Working up by chromatography analogously to Example 63 yields the purified title compound in the form of a viscous oil; MS (+FAB method): m/z (rel. int.[%])=591 ([M+H]+, 7), 229 (86), 109 (100). For further analysis, a portion of the compound is converted into the hydrochloric acid salt and is extracted from ether in the form of a dry foam by stirring; m.p.: 123°-125° C. (ether).

1. customPreparation
2. customWorking up by chromatography analogously to Example 63 yields the
3. custompurified title compound in the form of a viscous oil
4. extractionis extracted from ether in the form of a dry foam