反应详情

To a solution of 4-(4-{1-[4-(tert-butyl-dimethylsiloxy)-3-methylphenyl]-1-ethylpropyl}-2-methylphenyl)-2-methylbutan-2-ol (0.25 g, 0.50 mmol) in anhyd THF (1.5 mL) was added a 1.0M solution of TBAF in THF (0.70 mL, 0.70 mmol). After 1.5 h the reaction mixture was diluted with EtOAc (30 mL), washed with satd NH4Cl (20 mL) and brine, then dried (Na2SO4) and concentrated under reduced pressure. The crude material was chromatographed (silica, EtOAc/Hex, 0:100 to 40:60) to yield the title compound (0.14 g, 74%) as a white tacky solid: 1H-NMR (C6D6) δ 7.23-7.28 (2H, m), 7.16-7.22 (2H, m), 7.11 (1H, dd, J=2.3, 8.3), 6.64 (1H, d, J=8.3), 5.39 (1H, br s), 2.66 (2H, m), 2.25 (6H, s), 2.21 (4H, q, J=7.3), 1.62 (2H, m), 1.14 (6H, t, J=7.3).

1. washwashed with satd NH4Cl (20 mL) and brine
2. dry with materialdried (Na2SO4)
3. concentrationconcentrated under reduced pressure
4. customThe crude material was chromatographed (silica, EtOAc/Hex, 0:100 to 40:60)