反应详情

The title compound was prepared from the product of Example 34A and commercially available 2-fluoro-6-trifluoromethyl-benzoyl chloride according to the procedure described for Example 1C. 1H NMR (DMSO-d6, 300 MHz) δ0.92 (t, J=7.1Hz, 3H), 1.60-1.72 (m, 3H), 1.98-2.17 (m, 3H), 2.57 (d, J=17.0Hz, 1H), 3.10 (dd, J=17.1, 4.9Hz, 1H), 4.15 (t, J=6.4 Hz, 2H), 4.69-4.73 (m, 1H), 5.14-5.16 (m, 1H), 7.73-7.87 (m, 3H), 11.53 (br s, 1H); MS (ESI+) m/z 458 (M+H)+. Anal. calcd. for C21H19F4NO4S: C, 55.14; H, 4.19; N; 3.06. Found: C, 55.19; H, 3.99; N, 3.08.