反应详情

To a solution of 2-(4-aminophenyl)-1-ethyl-6-methoxy-1H-indole-3-carbonitrile (50 mg, 0.172 mmol) in THF (2 mL) is added 2-chloroethyl isocyanate (22 uL, 0.258 mmol) at room temperature. After stirring overnight at reflux, the reaction mixture is concentrated in vacuo and the residue is diluted with ethyl acetate. The resulting semi-solid is triturated with hexane and the precipitate collected is collected by filtration and washed well with 50% ethyl acetate in hexane and dried in vacuo to afford (62 mg, 91%) of 1-(2-chloroethyl)-3-[4-(3-cyano-1-ethyl-6-methoxy-1H-indol-2-yl)-phenyl]-urea.

1. temperatureat reflux
2. concentrationthe reaction mixture is concentrated in vacuo
3. additionthe residue is diluted with ethyl acetate
4. customThe resulting semi-solid is triturated with hexane
5. customthe precipitate collected
6. filtrationis collected by filtration
7. washwashed well with 50% ethyl acetate in hexane
8. customdried in vacuo