反应详情

温度

80 °C

(4-Benzyloxy-2-fluoro-5-methoxy-phenyl)-(1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-methanol (84, 1.49 g, 2.79 mmol) was dissolved in acetonitrile (50 mL) and trifluoroacetic Acid (1.1 mL) was added. The reaction was stirred for 5 minutes. Triethylsilane (2.2 mL) was added to the reaction. The reaction was heated at 80° C. for 6 hours. The reaction was concentrated and the crude material was dissolved into ethyl acetate and washed with 1 N HCl, saturated sodium bicarbonate, and brine. The organic portion was dried over anhydrous sodium sulfate and concentrated. The solid obtained was used in the next reaction without further purification (85, 833 mg, 83%). MS (ESI) [M+H+]+=363.4.

1. concentrationThe reaction was concentrated
2. dissolutionthe crude material was dissolved into ethyl acetate
3. washwashed with 1 N HCl, saturated sodium bicarbonate, and brine
4. dry with materialThe organic portion was dried over anhydrous sodium sulfate
5. concentrationconcentrated
6. customThe solid obtained
7. customwas used in the next reaction without further purification (85, 833 mg, 83%)