反应详情

To a solution of tert-butylamine (366 mg, 5 mmol) in anhydrous hexane (20 mL) at 0° C. was added titanium(IV) chloride (133 mg, 0.5 mmol). After 5 min, the cooling bath was removed and 4-propylcyclohexanone (140 mg, 1 mmol) was added in one portion. The resulting mixture was stirred at ambient temperature for 2 h. Then, the precipitated solid was filtered and washed with anhydrous ethyl ether. The filtrate and washings were combined and concentrated under reduced pressure. The residue was dissolved in THF (20 mL) and treated with 5-chloro-2-methoxybenzoyl isothiocyanate (190 mg, 0.83 mmol) for 1 h at room temperature. Iodine (211 mg, 0.83 mmol) was added followed by addition of MeOH (10 mL) and pyridine (1 mL). The mixture was allowed to stir at room temperature for additional 2 h and then saturated sodium bicarbonate solution and ethyl ether were added. The mixture was stirred for 30 min, the ether layer was separated and the aqueous solution was extracted with ethyl ether. The ether extracts were combined, washed with brine, dried with anhydrous MgSO4 and concentrated under reduced pressure. The residue was twice evaporated with toluene and acetonitrile and then purified by chromatography (hexane-EtOAc 1:1) to afford 70 mg of the title compound. 1H NMR (300 MHz, DMSO-d6) δ ppm 0.85-1.02 (m, 3H), 1.29-1.53 (m, 6H), 1.68 (s, 9H), 1.90-2.07 (m, 1H), 2.19 (dd, J=15.9, 10.2 Hz, 1H), 2.78-3.01 (m, 2H), 3.09-3.26 (m, 1H), 3.72-3.84 (m, 3H), 7.11 (d, J=8.8 Hz, 1H), 7.45 (dd, J=8.8, 3.1 Hz, 1H), 7.68 (d, J=3.1 Hz, 1H); MS (DCI/NH3) m/z 421 (M+H)+. Anal. calcd for C22H29ClN2O2S.0.1H2O: C, 62.50; H, 6.96; N, 6.63. Found: C, 62.21; H, 6.99; N, 6.49.

1. customthe cooling bath was removed
2. filtrationThen, the precipitated solid was filtered
3. washwashed with anhydrous ethyl ether
4. concentrationconcentrated under reduced pressure
5. dissolutionThe residue was dissolved in THF (20 mL)
6. stirringto stir at room temperature for additional 2 h
7. stirringThe mixture was stirred for 30 min
8. customthe ether layer was separated
9. extractionthe aqueous solution was extracted with ethyl ether
10. washwashed with brine
11. dry with materialdried with anhydrous MgSO4
12. concentrationconcentrated under reduced pressure
13. customThe residue was twice evaporated with toluene and acetonitrile
14. custompurified by chromatography (hexane-EtOAc 1:1)