反应详情

A suspension of 2-amino-6-(2-furyl)pyrimidine-4-carboxylic acid (206 mg, 1.0 mmol) in DMF (5 mL) was treated with N,N′-carbonyldiimidazole (162 mg, 1.0 mmol), stirred for 2 h, treated with 3-methylpyridine-2-methanamine (244 mg, 2.0 mmol), stirred for 2 h, poured onto water (50 mL) and extracted with EtOAc (2×25 mL). The extracts were washed with water, concentrated in vacuo, and the crude product was triturated with ether to give the title compound (109 mg, 35%) as a yellow solid.

1. stirringstirred for 2 h
2. additionpoured onto water (50 mL)
3. extractionextracted with EtOAc (2×25 mL)
4. washThe extracts were washed with water
5. concentrationconcentrated in vacuo
6. customthe crude product was triturated with ether