反应详情

A solution of 7-[2-(2-formamidothiazol-4-yl)-2-cyanomethoxyiminoacetamido]-3-(1-methyl-1H-tetrazol-5-yl)thiomethyl-3-cephem-4-carboxylic acid (syn isomer, 2.05 g.) and conc. hydrochloric acid (1.52 g.) in methanol (30 ml.) and tetrahydrofuran (20 ml.) was stirred at room temperature for 2 hours. After the solvent was evaporated in vacuo, the residue was dissolved in 10% aqueous solution of sodium hydroxide. After filtration, the filtrate was adjusted to pH 3.0 with 10% hydrochloric acid and stirred under ice-cooling for 30 minutes. The precipitates were collected by filtration, washed with water and dried to give 7-[2-(2-aminothiazol-4-yl)-2-cyanomethoxyiminoacetamido]-3-(1-methyl-1H-tetrazol-5-yl)thiomethyl-3-cephem-4-carboxylic acid (syn isomer, 1.25 g.).

1. customAfter the solvent was evaporated in vacuo
2. dissolutionthe residue was dissolved in 10% aqueous solution of sodium hydroxide
3. filtrationAfter filtration
4. temperaturecooling for 30 minutes
5. filtrationThe precipitates were collected by filtration
6. washwashed with water
7. customdried