反应详情

Following the same procedure described in Example 42(h), 0.4 g of t-butyl α-[6-amino-5-oxo-2-(2-thienyl)perhydro-1,4-thiazepin-4-yl]acetate [prepared as described in Example 49(g)] was N-alkylated using 0.80 g of benzyl 2-bromo-4-phenylbutyrate. The resulting product was subjected to silica gel column chromatography eluted with a 1:40 by volume mixture of ethyl acetate and methylene chloride to separate it into two isomers, A and B, (ascribed to the asymmetric carbon atom to which the phenethyl group is attached).

1. washeluted with a 1:40 by volume mixture of ethyl acetate and methylene chloride
2. customto separate it into two isomers