反应详情

By using an analogous procedure to that described for Reference Example 14, benzyl (3S)-3-{[(benzyloxy)carbonyl]amino}-4-[(3,3-diethoxypropyl)amino]-4-oxobutanoate (2.63 g, 5.41 mmol, obtained from Reference Example 23) in tetrahydrofuran (11 ml) was reacted with 0.5 N hydrochloric acid at room temperature for 1 hour, to provide benzyl (3S)-3-{[(benzyloxy)carbonyl]amino}-4-oxo-4-[(3-oxopropyl)amino]butanoate (2.05 g, 92%) as a pale yellow waxy solid.