反应详情

1.75 g. (10 mmole) 4-Methoxy-1-naphthol is boiled under reflux for 2.5 hours in 18 ml. acetic anhydride. Thereafter, the solution is evaporated in a vacuum and the oily residue purified by column chromatography (silica gel; toluene/ethyl acetate 40:1 v/v). After evaporation of the appropriate fractions, the crude product is recrystallised from petroleum ether (b.p. 90°-110° C.). Yield 1.27 g. (58% of theory) of colourless crystals; m.p. 51°-53° C.

1. temperatureunder reflux for 2.5 hours in 18 ml
2. customThereafter, the solution is evaporated in a vacuum
3. customthe oily residue purified by column chromatography (silica gel; toluene/ethyl acetate 40:1 v/v)
4. customAfter evaporation of the appropriate fractions
5. customthe crude product is recrystallised from petroleum ether (b.p. 90°-110° C.)