反应详情

By using an analogous procedure to that described for Example 45, tert-butyl (5R,12S)-12-[(R)-[(3R,4R,5R)-3,4-bis{[tert-butyl(dimethyl)silyl]oxy}-5-(3-(4-methoxybenzyl)-2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl)tetrahydro-2-furanyl](hydroxy)methyl]-5-isobutyl-3,6-dioxo-1-phenyl-2-oxa-4,7,11-triazatridecan-13-oate (21 mg, 0.02 mmol, obtained from Example 56) was hydrogenated in methanol (2 ml) using 10% palladium on carbon (10 mg) for 3.5 hours to provide tert-butyl (2S,3R)-2-[(3-{[(2R)-2-amino-4-methylpentanoyl]amino}propyl)amino]-3-[(3R,4R,5R)-3,4-bis{[tert-butyl(dimethyl)silyl]oxy}-5-(3-(4-methoxybenzyl)-2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl)tetrahydro-2-furanyl]-3-hydroxypropanoate (14 mg, 78%) as a white solid.

1. customfor 3.5 hours