反应详情

6-(2-Methoxyphenyl)-2,2-dimethyl-4-(1-phenethyloxyethyl)-1,2-dihydroquinoline 4-(1-Hydroxyethyl)-6-(2-methoxyphenyl)-2,2-dimethyl-2H-quinoline-1-carboxylic acid tert-butyl ester (100 mg) was treated with 360 μL of 1 M solution of sodium bis(trimethylsilyl)amide in THF and 45 μL of phenethyl bromide to give the alkylated product, which was deprotected to yield 62 mg of the title compound as an oil.

1. customto give the alkylated product, which