反应详情

2,2,4-Trimethyl-6-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1,2-dihydroquinoline (308 mg) and 393 mg of 2-chloro-3-iodophenol were coupled using of 100 mg of PdCl2(dppf) and 300 mg of KOAc to give 250 mg of 2-chloro-3-(2,2,4-trimethyl-1,2-dihydroquinolin-6-yl)-phenol. Using the procedures described in Example 7, this (85 mg) was reacted with NBS to give 56 mg of 3-(4-bromomethyl-2,2-dimethyl-1,2-dihydroquinolin-6-yl)-2-chlorophenol. The product (50 mg) was coupled with 0.04 mL of 2-phenylethanethiol to give 40 mg of the title compound as an oil.