HRID258622

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID20322240

未命名化合物

结构：CCOC(=O)CCCCCCNS(=O)(=O)CCC#CC1(OC(C)=O)CCCCCCC1

HCID20327721

未命名化合物

HCID22793816

未命名化合物

PRODUCTS

生成物

结构：CS(=O)(=O)N(CCCCCCC(=O)O)CCCC1(O)CCCCCCC1

HCID20327691

未命名化合物

结构：CCCCCC(/C=C/CN(CCCCCC(CC)C(=O)O)S(C)(=O)=O)OC(C)=O

HCID20327696

未命名化合物

PROCEDURE

实验过程

The synthesis of this compound is carried out as described in Example 3, except that, in Step A, the 1-bromo-4(R)-acetoxy-2-nonyne is replaced by an equimolar amount of 1-acetoxy-1-(3-bromo-1-propynyl)cyclooctane (Example V). The product of Step A is thus ethyl 7-{[3-(1-acetoxycyclooctyl)-2-propynyl]methanesulfonamido}heptanoate. The subsequent steps yield 7-{N-[3-(1-hydroxycyclooctyl)-2-propynyl]methanesulfonamido}heptanoic acid (B) and 7-{N-[3(1-hydroxycyclooctyl)propyl]methanesulfonamido}heptanoic acid (C).

WORKUP

后处理

customThe synthesis of this compound

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f76e47127b6f4d47b89046b4103d4898
来源数据集: uspto-grants-1977_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04033996
来源说明: uspto-grants-1977_07

反应 SMILES

Br[CH2:2][C:3]#[C:4][C@H:5]([O:11][C:12](=[O:14])[CH3:13])[CH2:6][CH2:7][CH2:8][CH2:9][CH3:10].[C:15]([O:18][C:19]1([C:27]#[C:28][CH2:29]Br)[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1)(=O)[CH3:16].C(OC1(C#CC[CH2:46][S:47]([NH:50][CH2:51][CH2:52][CH2:53][CH2:54][CH2:55][CH2:56][C:57]([O:59]CC)=[O:58])(=[O:49])=[O:48])CCCCCCC1)(=O)C>>[CH2:15]([CH:56]([CH2:55][CH2:54][CH2:53][CH2:52][CH2:51][N:50]([CH2:2]/[CH:3]=[CH:4]/[CH:5]([O:11][C:12](=[O:14])[CH3:13])[CH2:6][CH2:7][CH2:8][CH2:9][CH3:10])[S:47]([CH3:46])(=[O:48])=[O:49])[C:57]([OH:59])=[O:58])[CH3:16].[OH:18][C:19]1([CH2:27][CH2:28][CH2:29][N:50]([CH2:51][CH2:52][CH2:53][CH2:54][CH2:55][CH2:56][C:57]([OH:59])=[O:58])[S:47]([CH3:46])(=[O:49])=[O:48])[CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26]1