反应详情

A mixture of 5.68 parts of 3-(2,3-dihydro-5-methyl-2-oxo-1H-benzimidazol-1-yl)propyl methanesulfonate, 4.8 parts of (4-fluorophenyl) (4-piperidinyl) methanone hydrochloride, 3.7 parts of sodium carbonate and 45 parts of N,N-dimethylformamide is stirred for 1 hour at 50°-60° C. The reaction mixture is cooled to room temperature and poured onto water. The product is extracted with trichloromethane. The extract is dried, filtered and evaporated. The residue is purified by column-chromatography over silica gel using a mixture of trichloromethane and 10% of methanol as eluent. The pure fractions are collected and the eluent is evaporated. The residue is crystallized from 4-methyl-2-pentanone. The product is filtered off and recrystallized twice from 4-methyl-2-pentanone, yielding 0.5 parts (6.5%) of 1-{3-[4-(4-fluorobenzoyl)-1-piperidinyl]propyl}-1,3-dihydro-5-methyl-2H-benzimidazol-2-one; mp. 149° C.

1. additionpoured onto water
2. extractionThe product is extracted with trichloromethane
3. customThe extract is dried
4. filtrationfiltered
5. customevaporated
6. customThe residue is purified by column-chromatography over silica gel using
7. additiona mixture of trichloromethane and 10% of methanol as eluent
8. customThe pure fractions are collected
9. customthe eluent is evaporated
10. customThe residue is crystallized from 4-methyl-2-pentanone
11. filtrationThe product is filtered off
12. customrecrystallized twice from 4-methyl-2-pentanone