反应详情

A mixture of 2.9 g (0.007 mole) of 6-(2-chlorophenyl)-1,8-dichloro-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid methyl ester, 1.1 g (0.02 mole) of sodium methoxide and 100 ml of dry methanol was heated in a steel bomb at 115°-120° for 20 hrs. The solvent was removed at reduced pressure. The residue was dissolved in methylene chloride, washed with dilute hydrochloric acid to give pale yellow amorphous solid. An ethereal solution (60 ml) of the solid was washed with dilute ammonium hydroxide solution, dried, filtered and concentrated on a steam bath to about 20 ml. White crystals were obtained after keeping the solution at room temperature for several hours with occasional scratching. Recrystallization from ether gave white crystals with mp 155°-160°. Uv λ sh 213 mμ (ε=36,000) max 266 (20,500) ir (CHCl3) 1715 cm-1 (COOCH3); nmr (CDCl3) δ 3.93 ppm (s, 3, COOCH3) 4.23 (s, 3, OCH3) 4.08 (d, 1) and 6.06 (d, 1) AB-system, J=12 Hz, C4 -H) 7.1-7.9 (m, 7, aromatic H).

1. customThe solvent was removed at reduced pressure
2. dissolutionThe residue was dissolved in methylene chloride
3. washwashed with dilute hydrochloric acid
4. customto give pale yellow amorphous solid
5. washAn ethereal solution (60 ml) of the solid was washed with dilute ammonium hydroxide solution
6. customdried
7. filtrationfiltered
8. concentrationconcentrated on a steam bath to about 20 ml
9. customWhite crystals were obtained
10. customat room temperature
11. customfor several hours
12. customRecrystallization from ether
13. customgave white crystals with mp 155°-160°