反应详情

To a solution prepared by dissolving the resulting 2.88 g of 4-(3-chloro-5-trifluoromethyl-2-pyridyloxy)phenol in 300 ml of chloroform, 4.80 g of tetra-n-butyl ammonium tribromide was slowly added with stirring under room temperature. After 12 hours, the reaction solution was concentrated, and the residue was extracted twice with 100 ml of diethyl ether. Then, the ether layers were combined, washed with water, dried over anhydrous magnesium sulfate and then concentrated to give a crude product. This crude product was subjected to silica gel chromatography to give 2.53 g of 2-bromo-4-(3-chloro-5-trifluoromethyl-2-pyridyloxy)phenol (yield, 69%).

1. customTo a solution prepared
2. additionwas slowly added
3. concentrationthe reaction solution was concentrated
4. extractionthe residue was extracted twice with 100 ml of diethyl ether
5. washwashed with water
6. dry with materialdried over anhydrous magnesium sulfate
7. concentrationconcentrated
8. customto give a crude product