反应详情

8.1 g (0.07 mol) of methanesulphonyl chloride are run, at about 10° C., into a solution of 19.5 g (0.07 mol) of (±)-2-[4-(4-chlorophenoxy)-phenoxy]-1-propanol (CRL 40 300) prepared as indicated in Example 27, in 35 ml of pyridine. The reaction mixture is stirred for 1 hour at ambient temperature and is poured onto ice. The insoluble matter is extracted with diethyl ether and the organic phase obtained is washed with dilute hydrochloric acid and dried, to give a white pasty residue after evaporation of the solvent. The solidification of this residue is petroleum ether gives 24 g of a white powder which is insoluble in water.

1. customprepared
2. additionis poured onto ice
3. extractionThe insoluble matter is extracted with diethyl ether
4. customthe organic phase obtained
5. washis washed with dilute hydrochloric acid
6. customdried
7. customto give a white pasty residue
8. customafter evaporation of the solvent