反应详情

Analogously to Example 1j), 2.7 g (6.25 mmol) of 5(S)-(Boc-amino)-4(S)-hydroxy-6-phenyl-2(R)-(m-fluorophenylmethyl)-hexanoic acid in 30 ml of DMF are silylated with 4.33 g (28.8 mmol) of tert-butyldimethylchlorosilane and 3.51 g (51.3 mmol) of imidazole. Hydrolysis of the silyl ester function with 5.1 g of potassium carbonate in 100 ml of methanol/THF/water 4:1:1 yields the title compound after column chromatography (SiO2, hexane/ethyl acetate 2:1): tRet (I)=20.8 min.