反应详情

2-[3-(3,4-Dichloro-phenyl)-1-(3,4,5-trimethoxy-benzoyl)-pyrrolidin-3-yl]-ethyl-methanesulfonate (7.87 mmol) and THF/H20 (3/1, 80 mL) were combined. 4-Phenyl-piperidine-4-carboxylic acid amide hydrochloride (2.8 g, 11.64 mmol, 1.5 eq.) and potassium carbonate (3.3 g, 23.88 mmol, 3 eq.) were added. The mixture was heated to reflux for 72 h. The mixture was concentrated in in vacuo. The aqueous residue was extracted with dichloromethane. The organic phase was extracted with H2O (50 mL). The organic phase was dried over MgSO4, filtered, and concentrated in uacuo to obtain a residue. The residue was purified by chromatography on silica gel (350 g) eluting sequentially with ethyl acetate, 6% methanol in dichloromethane, and then 10% methanol in dichloromethane to give the title compound:

1. temperatureThe mixture was heated
2. temperatureto reflux for 72 h
3. concentrationThe mixture was concentrated in in vacuo
4. extractionThe aqueous residue was extracted with dichloromethane
5. extractionThe organic phase was extracted with H2O (50 mL)
6. dry with materialThe organic phase was dried over MgSO4
7. filtrationfiltered
8. concentrationconcentrated in uacuo
9. customto obtain a residue
10. customThe residue was purified by chromatography on silica gel (350 g)
11. washeluting sequentially with ethyl acetate, 6% methanol in dichloromethane