反应详情

The title compound was prepared from 4-(3-piperidin-1-ylpropoxy)benzoyl chloride hydrochloride (D3) (0.20 g) and 6-cyano-1,2,3,4-tetrahydroisoquinoline hydrochloride (WO98/50363) (0.15 g) using the procedure described for Example 1 and isolated as a white solid (0.13 g). MS electrospray (+ion) 404 (MH+). 1H NMR δ (DMSO-d6): 10.20 (1H, s), 7.69 (1H, s), 7.65 (1H, d, J=7.5 Hz), 7.45 (3H, m), 7.02 (2H, d, J=8.6 Hz), 4.76 (1H, s), 4.11 (1H, t, J=5.9), 3.68 (2H, m), 3.44 (2H, m), 3.17 (2H, m), 2.90 (4H, m), 2.19 (2H, m), 1.78-1.37 (6H, m).