反应详情

400 mg (0.765 mmol) of benzyl{(1S)-4-[(tert-butoxycarbonyl)amino]-1-[2-({2-[(tert-butoxycarbonyl)amino]ethyl}amino)-2-oxoethyl]butyl}carbamate (Example 114A) are dissolved in 50 ml of ethanol. 80 mg of palladium on activated carbon (10%) are added thereto, and the mixture is then hydrogenated under atmospheric pressure for 15 h. The reaction mixture is filtered through prewashed kieselguhr, and the filtrate is concentrated on a rotary evaporator in vacuo. The crude product is reacted without further purification.

1. filtrationThe reaction mixture is filtered through prewashed kieselguhr
2. concentrationthe filtrate is concentrated on a rotary evaporator in vacuo
3. customThe crude product is reacted without further purification