HRID269641

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)OC(=O)NCCC[C@@H](CNC(=O)[C@H](CCCNC(=O)OC(C)(C)C)NC(=O)OCc1ccccc1)NC(=O)OC(C)(C)C

HCID86624497

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)NCCC[C@@H](CNC(=O)[C@@H](N)CCCNC(=O)OC(C)(C)C)NC(=O)OC(C)(C)C

HCID86624530

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID23938

Palladium

溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

Preparation takes place in analogy to Example 81A from 132 mg (0.20 mmol) of benzyl{(1S)-1-[({(2S)-2,5-bis[(tert-butoxycarbonyl)amino]pentyl}amino)carbonyl]-4-[(tert-butoxycarbonyl)amino]butyl}carbamate (Example 119A) in 50 ml of ethanol with the addition of 13 mg of palladium on activated carbon (10%). The product is reacted without further purification.

WORKUP

后处理

customPreparation
customThe product is reacted without further purification

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d298cf61992643f98bff20aa0711c269
来源数据集: uspto-grants-2008_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07446102B2
来源说明: uspto-grants-2008_11

反应 SMILES

C(OC(=O)[NH:10][C@H:11]([C:23]([NH:25][CH2:26][C@@H:27]([NH:39][C:40]([O:42][C:43]([CH3:46])([CH3:45])[CH3:44])=[O:41])[CH2:28][CH2:29][CH2:30][NH:31][C:32]([O:34][C:35]([CH3:38])([CH3:37])[CH3:36])=[O:33])=[O:24])[CH2:12][CH2:13][CH2:14][NH:15][C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])C1C=CC=CC=1>C(O)C.[Pd]>[C:19]([O:18][C:16](=[O:17])[NH:15][CH2:14][CH2:13][CH2:12][C@H:11]([NH2:10])[C:23]([NH:25][CH2:26][C@@H:27]([NH:39][C:40]([O:42][C:43]([CH3:46])([CH3:45])[CH3:44])=[O:41])[CH2:28][CH2:29][CH2:30][NH:31][C:32]([O:34][C:35]([CH3:38])([CH3:36])[CH3:37])=[O:33])=[O:24])([CH3:20])([CH3:21])[CH3:22]