反应详情

Preparation takes place in analogy to Example 83A from 1.0 g (2.73 mmol) of N5-[(benzyloxy)carbonyl]-N2-(tert-butoxycarbonyl)-L-ornithine in 35 ml of tetrahydrofuran with 0.276 g (2.73 mmol) of 4-methylmorpholine, 0.296 g (2.73 mmol) of ethyl chloroformate and 5.5 ml (5.5 mmol) of a 1M solution of lithium aluminum hydride in tetrahydrofuran. The product is purified by preparative HPLC (Kromasil, mobile phase acetonitrile/0.25% aqueous trifluoroacetic acid 5:95→95:5).

1. customPreparation
2. customThe product is purified by preparative HPLC (Kromasil, mobile phase acetonitrile/0.25% aqueous trifluoroacetic acid 5:95→95:5)