反应详情

Part C: 4-Cyano-2-fluoro-N—((S)-1-{4-[4-(5-methyl-[1,2,4]oxadiazol-3-yl)-phenyl]-1H-imidazol-2-yl}-2-phenyl-ethyl)-benzamide: The compound of Example 183 Part B was coupled to 4-cyano-2-fluorobenzoic acid using the procedure of Example 176 Part B to provide the amide in 90% yield. 1H NMR (500 MHz, CDCl3) δ ppm 2.64 (s, 3 H) 3.43 (dd, J=13.75, 7.15 Hz, 1 H) 3.58 (dd, J=13.75, 7.70 Hz, 1 H) 5.38 (q, J=7.15 Hz, 1 H) 7.20-7.33 (m, 7 H) 7.42 (d, J=9.90 Hz, 1 H) 7.54 (d, J=8.25 Hz, 2 H) 7.86 (s, 1 H) 8.05 (d, J=8.25 Hz, 2 H) 8.14 (t, J=7.70 Hz, 1 H) 9.43 (s, 1 H). m/z 493.1 (M+H)+.