反应详情

To 15 mg of (2R)-1-{(2S,4R)-4-hydroxy-1-(3,3,3-triphenylpropanoyl)pyrrolidin-2-yl}carbonyl-N-{((3S)-1-methyl-3-piperidyl)methyl}pyrrolidine-2-carboxamide, 0.5 ml of 10% methyl bromide-acetonitrile was added at room temperature, followed by 12 hours' stirring. The solvent in the reaction liquid was distilled off under reduced pressure, and the resulting residue was purified by preparative thin-layer chromatography (aluminium oxide 60F254, Art. 5713 (Merck), choroform/methanol=18/1) to provide 15 mg of the title compound as a white solid.

1. customThe solvent in the reaction liquid
2. distillationwas distilled off under reduced pressure
3. customthe resulting residue was purified by preparative thin-layer chromatography (aluminium oxide 60F254, Art. 5713 (Merck), choroform/methanol=18/1)