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4-[6-(8-Cyclopentyl-6-isobutoxy-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-ylamino)-pyridin-3-yl]-piperazine-1-carboxylic acid tert-butyl ester (0.067 g, 0.119 mmol) was dissolved in chloroform (5 ml), cooled to 0° C. This solution was purged with anhydrous hydrogen chloride gas and stoppered for 3 hours. Diethyl ether was added to the mixture giving a precipitate that was filtered and dried in vacuo to provide 8-cyclopentyl-6-isobutoxy-2-(5-piperazin-1-yl-pyridin-2-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one hydrochloride as a solid (0.056 g). MS (APCI); M++1: Calc'd, 464.5. Found, 464.3. Analyses for C25H33N7O2.1.0H2O.2.0HCl: Calc'd: C, 54.15; H, 6.72; N, 17.68, Cl (ionic), 12.78; H2O, 3.25. Found: C, 54.18; H, 6.98; N, 17.51; Cl (ionic), 12.15; H2O, 2.60.

1. customThis solution was purged with anhydrous hydrogen chloride gas
2. additionDiethyl ether was added to the mixture
3. customgiving a precipitate that
4. filtrationwas filtered
5. customdried in vacuo