反应详情

2N HCl (5 mL) was added to 3-[1,3]dioxolan-2-yl-6-methoxy-2-methyl-benzofuran in THF (5 mL) at 0° C. After stirring for 1 h at room temperature, the solvent was removed under reduced pressure. The residue was dissolved in EtOAc and washed with saturated NaHCO3. The aqueous layer was extracted with EtOAc (3×20 mL). The organic layers were combined and dried over anhydrous MgSO4. After the solvent was removed, the residue was purified on a silica gel column eluting with EtOAc/hexane (1:9) to give 6-methoxy-2-methylbenzofuran-3-carbaldehyde (0.090 g, 81%).

1. customthe solvent was removed under reduced pressure
2. dissolutionThe residue was dissolved in EtOAc
3. washwashed with saturated NaHCO3
4. extractionThe aqueous layer was extracted with EtOAc (3×20 mL)
5. dry with materialdried over anhydrous MgSO4
6. customAfter the solvent was removed
7. customthe residue was purified on a silica gel column
8. washeluting with EtOAc/hexane (1:9)