反应详情

To a solution of tert-butyl 3-{4-[(4′-{[tert-butyl(dimethyl)silyl]oxy}-2′,6′-dimethylbiphenyl-3-yl)methoxy]phenyl}propanoate (2.38 g, 4.35 mmol) in tetrahydrofuran (24 mL) was added tetrabutylammonium fluoride (1 M tetrahydrofuran solution, 4.79 mmol, 4.79 mL) at room temperature with stirring and the mixture was stirred at room temperature for 2 hrs. The reaction mixture was concentrated under reduced pressure and the residue was partitioned between water and ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane/ethyl acetate=10/1-hexane/ethyl acetate=3/1) to give the title compound (1.69 g, yield 90%) as a colorless oil.

1. stirringthe mixture was stirred at room temperature for 2 hrs
2. concentrationThe reaction mixture was concentrated under reduced pressure
3. customthe residue was partitioned between water and ethyl acetate
4. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
5. concentrationconcentrated under reduced pressure
6. customThe residue was purified by silica gel column chromatography (hexane/ethyl acetate=10/1-hexane/ethyl acetate=3/1)