反应详情

A mixture of ethyl 3-[4-({4′-[2-(ethylamino)ethoxy]-2′,6′-dimethylbiphenyl-3-yl}methoxy)-2-fluorophenyl]propanoate (0.27 g, 0.55 mmol), 4-dimethylaminopyridine (7 mg, 55 μmol), acetic anhydride (0.10 mL, 1.09 mmol) and pyridine (5.4 mL) was stirred at room temperature for 62 hrs. The reaction mixture was concentrated and the residue was purified by silica gel column chromatography (hexane/ethyl acetate=9/1-ethyl acetate) to give the title compound (0.25 g, yield 85%) as a colorless oil.

1. concentrationThe reaction mixture was concentrated
2. customthe residue was purified by silica gel column chromatography (hexane/ethyl acetate=9/1-ethyl acetate)