反应详情

Hydrogenate 3.72 of 7-(4-nitrobenzyl)perhydroazepin-2-one in 50 mls of ethyl alcohol with platinum/hydrogen. After the absorption of hydrogen has ceased, filter off the catalyst and concentrate the filtrate. Dissolve the thus obtained 7-(4-aminobenzyl)-perhydroazepin-2-one in tetrahydrofuran. Add 680 mg of lithium aluminum hydride and boil the mixture under reflux. After cooling, treat it with ice-water and extract it with diethyl Dry the organic phase over sodium sulphate and concentrate it to obtain 2.0 g of the brown oily title compound.

1. customAfter the absorption of hydrogen
2. filtrationfilter off the catalyst
3. concentrationconcentrate the filtrate
4. dissolutionDissolve the thus obtained 7-(4-aminobenzyl)-perhydroazepin-2-one in tetrahydrofuran
5. additionAdd 680 mg of lithium aluminum hydride and boil the mixture
6. temperatureunder reflux
7. temperatureAfter cooling
8. additiontreat it with ice-water
9. extractionextract it with diethyl
10. dry with materialDry the organic phase over sodium sulphate
11. concentrationconcentrate it