反应详情

9.96 ml (124.5 mmol) of cyclopropyl bromide in 100 ml of ether were added dropwise within 30minutes to 3.03 g (124.5 mmol) of magnesium in 10 ml of abs. ether under slight reflux and the mixture was subsequently heated to reflux for 2 1/2 hours. Subsequently, 6.25 g (22.63 mmol) of tert-butyl [(1S,2R)-1-benzyl-2-cyano-2-hydroxyethyl]carbamate (EPA 0,266,950) were added dropwise thereto under reflux within 5 minutes and the mixture was heated to reflux for a further 2 1/2 hours. Finally, the mixture was left to cool (10°), 10% citric acid was added dropwise thereto and the mixture was extracted twice with ether. The organic phase was washed with water and saturated sodium chloride solution, dried over magnesium sulphate, filtered and evaporated under reduced pressure. Chromatography on silica gel using a 9:1 mixture of toluene and ethyl acetate yielded tert-butyl [(1S,2R)-1-benzyl-2-(cyclopropylcarbonyl)-2-hydroxyethyl]carbamate as a pale yellow solid, MS: 246 (M-C3H9O)+.

1. temperaturethe mixture was subsequently heated
2. temperatureto reflux for 2 1/2 hours
3. temperatureunder reflux within 5 minutes
4. temperaturethe mixture was heated
5. temperatureto reflux for a further 2 1/2 hours
6. waitFinally, the mixture was left
7. additionwas added dropwise
8. extractionthe mixture was extracted twice with ether
9. washThe organic phase was washed with water and saturated sodium chloride solution
10. dry with materialdried over magnesium sulphate
11. filtrationfiltered
12. customevaporated under reduced pressure
13. additionChromatography on silica gel using a 9:1 mixture of toluene and ethyl acetate