反应详情

To a solution of 1.8 g (10 mmol) of 1-allyl-3-(RS)-formyl-4-(SR)-(cyclopropyl)pyrrolidine and 2.68 g (15 mmol) of 4-(4-fluorophenyl)piperidine in 30 mL of dichloroethane at rt was added portionwise 6.36 g (30 mmol) of sodiumtriacetoxyborohydride. After stirring for 3 h at rt, the reaction mixture was partitioned between CH2Cl2 and sat'd K2CO3. The organic fraction was dried over MgSO4, filtered and the filtrate was concentrated. The residue was purified by chomatography (silica, ethyl acetate:hexanes, 1:3) to give 2.1 g of the title compound.

1. customthe reaction mixture was partitioned between CH2Cl2
2. dry with materialThe organic fraction was dried over MgSO4
3. filtrationfiltered
4. concentrationthe filtrate was concentrated
5. customThe residue was purified by chomatography (silica, ethyl acetate:hexanes, 1:3)