反应详情

温度

25 °C

A solution of methanesulfonyl chloride (4.2 mg, 0.037 mmol) in CHCl3 (1.0 mL) and (piperidinomethyl)polystyrene (54 mg, 2.7 mmol base/g resin) were added to a solution of 4-(benzyl)benzyl alcohol (8.7 mg, 0.044 mmol) in CHCl3 (1.0 mL). The reaction mixture was stirred at 25° C. for 15 h. A solution of 4-[{N-(3-(trifluoromethyl)benzoyl)glycyl}aminomethyl]piperidine (15.1 mg, 0.044 mmol) in CH3CN (1.0 mL) and KI (2 mg) were added to the reaction mixture and the mixture was stirred at 65° C. for 5 h. Phenyl isocyanate (5.2 mg) was added to the cooled reaction mixture and the mixture was stirred at 25° C. for 1 h. The reaction mixture was loaded onto Varian™ SCX column and washed with CH3OH (20 mL). Product was eluted off using 2 N NH3 in CH3OH (6 mL) and concentrated to afford 1-(4-benzylbenzyl)-4-[{N-(3-(trifluoromethyl)benzoyl)glycyl}aminomethyl]piperidine (compound No. 926) as a pale yellow oil (5.6 mg, 29): The purity was determined by RPLC/MS (94%); ESI/MS m/e 524.1 (M++H, C30H32F3N3O2).

1. stirringthe mixture was stirred at 65° C. for 5 h
2. stirringthe mixture was stirred at 25° C. for 1 h
3. washwashed with CH3OH (20 mL)
4. washProduct was eluted off
5. concentrationconcentrated