HCID 68852667, compound → HCID 68852070, compound

HRID 28842Notes

Reaction equation

HRID 28842 reaction equation
[ClH:1].Cl.[CH3:3][NH:4][C@@H:5]1[CH2:9][CH2:8][N:7]([CH2:10][CH:11](C2(O)CCCCC2)[C:12]2[CH:21]=[CH:20][C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[CH:13]=2)[CH2:6]1.[OH:29][C:30]1(C(C2C=CC3C(=CC=CC=3)C=2)C(N2CC[C@@H](NC(=O)OC(C)(C)C)C2)=O)[CH2:35][CH2:34][CH2:33][CH2:32][CH2:31]1>>[ClH:1].[ClH:1].[CH3:3][NH:4][C@@H:5]1[CH2:9][CH2:8][N:7]([CH2:10][CH:11]([CH:31]2[CH2:32][CH2:33][CH2:34][CH2:35][CH:30]2[OH:29])[C:12]2[CH:21]=[CH:20][C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[CH:13]=2)[CH2:6]1

Participants

3

Reactant 2

HCID 68852667HCID 68852667, compoundHCID 86599049tert-butyl{(3R)-1-[(1-hydroxycyclohexyl)(2-naphthyl)acetyl]pyrrolidin-3-yl}carbamate

Product 1

HCID 68852070HCID 68852070, compound

Procedure

In an analogous manner to Example 13, step 2, 1-[2-[(3R)-3-(methylamino]pyrrolidin-1-yl]-1-(2-naphthyl)ethyl]cyclohexanol dihydrochloride was prepared from tert-butyl {(3R)-1-[(1-hydroxycyclohexyl)(2-naphthyl)acetyl]pyrrolidin-3-yl}carbamate. MS m/z 353; HRMS: calcd for C23H32N2O+H+, 353.25874; found (ESI, [M+H]+), 353.2583.

Sources & evidence

ORD record
ord-d65590b8a5bb4c51bb14a87ecee43459
Source dataset
uspto-grants-2008_09
Patent number
US07419980B2

Reaction notes

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