反应详情

3-Methyl-4-(thiophene-2-sulfonylamino)-benzofuran-2-carboxylic acid ethyl ester was prepared from 4-amino-3-methyl-benzofuran-2-carboxylic acid ethyl ester (Example 60, Step 1), and 2-thiophenesulfonyl chloride according to the procedure of Example 68, Step 1. Yield: 68%. 1H NMR (400 MHz, DMSO-d6) δ ppm 1.3 (t, J=7.1 Hz, 3 H) 2.6 (s, 3 H) 4.4 (q, J=7.1 Hz, 2 H) 6.7 (dd, J=7.8, 0.8 Hz, 1 H) 7.2 (dd, J=4.9, 3.7 Hz, 1 H) 7.4 (m, 2 H) 7.6 (dd, J=8.3, 0.8 Hz, 1 H) 8.0 (dd, J=4.9, 1.4 Hz, 1 H) 10.2 (s, 1 H)