反应详情

To 220 mg (0.67 mmol) of 5-bromo-4-hydroxy-3-methyl-benzofuran-2-carboxylic acid tert-butyl ester was added 0.42 mL (6.7 mmol) of iodomethane, 185 mg (1.34 mmol) of K2CO3 and 2 mL of DMF. The mixture was stirred at room temperature over night. The mixture was washed with brine and extracted with ethyl acetate. The combined ethyl acetate layers were washed with brine. Removal of the solvent gave 230 mg (100% yield) of 5-bromo-4-methoxy-3-methyl-benzofuran-2-carboxylic acid tert-butyl ester as a colorless oil.

1. washThe mixture was washed with brine
2. extractionextracted with ethyl acetate
3. washThe combined ethyl acetate layers were washed with brine
4. customRemoval of the solvent